| Bioactivity | Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of protein phosphatase 2A (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth[1]. |
| Invitro | Ethoxysanguinarine inhibits cells vialibity with IC50 of 9.37 μM (SW480 cells); 7.19 μM (HCT116 cells); 6.55 μM (HT69 cells); 3.57 μM (SW620 cells)[1].Ethoxysanguinarine (3 μM or 5 μM, 24 h) down-regulates phospho-Akt, decreases CIP2A/PP2A/Akt pathway expression in the SW620 and HT29 cells[1].Ethoxysanguinarine (3 μM or 5 μM, 24 h) increases the PP2A activity and inhibits phosphorylation of CIP2A downstream molecule protein kinase B[1].Ethoxysanguinarine (1-3 μM or 4.5-5 μM, 24 h) decreases CIP2A transcription (protein level) and induces CIP2A proteolysis in the SW620 and HT29 cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | Ethoxysanguinarine |
| CAS | 28342-31-6 |
| Formula | C22H19NO5 |
| Molar Mass | 377.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
Ethoxysanguinarine
CAS: 28342-31-6 F: C22H19NO5 W: 377.39
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysan
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.