| Bioactivity | Etalocib (LY293111) sodium, an orally active leukotriene B4 receptor antagonist, inhibits the binding of [3H]LTB4, with a Ki of 25 nM. Etalocib sodium prevents LTB4-induced calcium mobilization with an lC50 of 20 nM. Etalocib sodium induces apoptosis[1][2][3]. |
| Invitro | Etalocib sodium 引发浓度依赖性抑制 LTB4 诱导的 CD11b 上调[1]。Etalocib sodium 是一种体外极其有效且选择性的人类中性粒细胞功能拮抗剂[2]。Etalocib (250 和 500 nM, 24-72 小时) sodium 诱导人胰腺癌细胞凋亡并抑制其增殖[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Etalocib sodium 相关抗体: |
| In Vivo | Etalocib produces a dose-related inhibition of acute leukotriene B4-induced airway obstruction when administered i.v. (ED50=14 μg/kg) or p.o. (ED50=0.4 mg/kg)[2].Etalocib (10 mg/kg) inhibits A23187-induced lung inflammatory changes at 1 h[2].Etalocib (250 mg/kg/day, orally) inhibits growth of human pancreatic cancer xenografts in athymic mice[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 152608-41-8 |
| Formula | C33H32FNaO6 |
| Molar Mass | 566.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. P Marder, et al. Blockade of Human Neutrophil Activation by 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- Hydroxyphenoxy]propoxy]phenoxy]benzoic Acid (LY293111), a Novel Leukotriene B4 Receptor Antagonist. Biochem Pharmacol. 1995 May 26;49(11):1683-90. [2]. S A Silbaugh, et al. Pharmacologic Actions of the Second Generation Leukotriene B4 Receptor Antagonist LY29311: In Vivo Pulmonary Studies. Naunyn Schmiedebergs Arch Pharmacol. 2000 Apr;361(4):397-404. [3]. Wei-Gang Tong, et al. Leukotriene B4 Receptor Antagonist LY293111 Inhibits Proliferation and Induces Apoptosis in Human Pancreatic Cancer Cells. Clin Cancer Res. 2002 Oct;8(10):3232-42. |
Etalocib sodium
CAS: 152608-41-8 F: C33H32FNaO6 W: 566.59
Etalocib (LY293111) sodium, an orally active leukotriene B4 receptor antagonist, inhibits the binding ofLTB4, with a Ki
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