| Bioactivity | Estrogen receptor antagonist 8 is a potent ER-antagonist with in vivo anti-uterotrophic potential (EC50 = 4.160 μM)[1]. |
| In Vivo | 在体内抗子宫营养试验中，通过测量未成熟雌性大鼠子宫重量与对照组相比的减少，建立了剂量-反应曲线。 Estrogen receptor antagonist 8 (s.c.; 1、3、10、20、30 mg/Kg/天; 3 d) 表现出比 TMX 更好的抗子宫萎缩潜能 (EC50: 7.625 μM), Estrogen receptor antagonist 8 的 EC50 值为 4.160 μM[1]。 |
| Name | Estrogen receptor antagonist 8 |
| CAS | 2889370-92-5 |
| Formula | C25H21N3O4 |
| Molar Mass | 427.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mahmoud A Ragab, et al. Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity. Bioorg Chem. 2022 Feb;119:105554. |
Estrogen receptor antagonist 8
CAS: 2889370-92-5 F: C25H21N3O4 W: 427.45
Estrogen receptor antagonist 8 is a potent ER-antagonist with in vivo anti-uterotrophic potential (EC50 = 4.160 μM)
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