| Bioactivity | Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity[1][2][3][4][5]. | ||||||||||||
| Invitro | Epoxomicin shows quite potent cytotoxicities against all of the cells tested. Epoxomicin inhibits the cells growth of B16-F10, HCT116, Moser, P388 and K562 cells of IC50 values of 0.002 μg/mL, 0.005 μg/mL, 0.044 μg/mL, 0.002 μg/mL and 0.037 μg/mL[1].Epoxomicin has antiproliferative activity with an IC50 of 4 nM in EL4 lymphoma cells[2]. | ||||||||||||
| Name | Epoxomicin | ||||||||||||
| CAS | 134381-21-8 | ||||||||||||
| Formula | C28H50N4O7 | ||||||||||||
| Molar Mass | 554.72 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
Epoxomicin
CAS: 134381-21-8 F: C28H50N4O7 W: 554.72
Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome i
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.