| Bioactivity | Epothilone D (KOS 862) is a potent microtubule stabilizer. | |||||||||
| Invitro | Epothilone D (KOS-862) is a more potent microtubule stabilizer in vitro than epothilone A or B. In vitro, Epothilone D has shown potent cytotoxicity in a panel of human tumor cell lines, with similar potency to paclitaxel. Epothilone D also shows a definite advantage over paclitaxel in drug-resistant cell lines, and retained its cytotoxicity against a multidrug resistant cell line over-expressing P-glycoprotein[1]. Epothilone D (EpoD) is a microtubules (MTs)-stabilizing agent[2]. | |||||||||
| Name | Epothilone D | |||||||||
| CAS | 189453-10-9 | |||||||||
| Formula | C27H41NO5S | |||||||||
| Molar Mass | 491.68 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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