Bioactivity | EphB1-IN-1 (Compound 1) is a potent EphB1 inhibitor with IC50s of 3.0, 15 and 220 nM against EphB1G703C, EphB1T697G and EphB1WT, respectively[1]. |
Target | IC50: 3.0 nM (EphB1G703C), 15 nM (EphB1T697G), 220 nM (EphB1WT) |
Invitro | EphB1-IN-1 (Compound 1) 和 3MB-PP1 (HY-102069) 导致同一细胞中两个 Eph 激酶的正交抑制[1]。 Western Blot Analysis[1] Cell Line: |
Name | EphB1-IN-1 |
CAS | 1980036-18-7 |
Formula | C16H12Cl2N4O2 |
Molar Mass | 363.20 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Kung A, et al. A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases. ACS Chem Biol. 2017 Jun 16;12(6):1499-1503. |