Ep300/CREBBP-IN-2

CAS: 2259641-59-1 F: C26H27F3N4O4 W: 516.51

Ep300/CREBBP-IN-2 (Example 73) is a potent and orally active Ep300 and CREBBP inhibitor with IC50s of 0.052 and 0.148 μ

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Bioactivity	Ep300/CREBBP-IN-2 (Example 73) is a potent and orally active Ep300 and CREBBP inhibitor with IC50s of 0.052 and 0.148 μM, respectively. Ep300/CREBBP-IN-2 can be used for the research of cancer[1].
Invitro	Ep300/CREBBP-IN-2 (Example 73) 抑制细胞内 H3K27Ac 活性，其 IC50 为 0.070 μM[1]。Ep300/CREBBP-IN-2 (38 nM-10 mM; 3 days) 抑制 LK2 和 TE-8 细胞生长，GI50 分别为 610.15 μM 和 619.505 μM [1]。 Cell Viability Assay[1] Cell Line:
In Vivo	Ep300/CREBBP-IN-2 (Example 73; 2 mg/kg/day; oral; twice daily for 9 days) 抑制小鼠肿瘤增殖[1]。 Animal Model:
Name	Ep300/CREBBP-IN-2
CAS	2259641-59-1
Formula	C26H27F3N4O4
Molar Mass	516.51
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. NAITO Hiroyuki, et al. EP300 / CREBBP inhibitor. Patent JPWO2018235966A1.

Ep300/CREBBP-IN-3