| Bioactivity | ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca2+?leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine.?ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies[1]. |
| Name | Ent-(+)-Verticilide |
| CAS | 2056011-05-1 |
| Formula | C44H76N4O12 |
| Molar Mass | 853.09 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Suzanne M Batiste, et al. Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4810-4815. |
Ent-(+)-Verticilide
CAS: 2056011-05-1 F: C44H76N4O12 W: 853.09
ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels wi
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.