| Bioactivity | Endomorphin 1, a high affinity, highly selective agonist of the μ-opioid receptor (Ki: 1.11 nM), displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. Endomorphin 1 has antinociceptive properties[1][2][4]. | ||||||
| Invitro | Endomorphin 1 inhibits Forskolin (HY-15371) (1 μM) stimulated cyclic AMP formation with a pIC50 value of 8.03 in In CHOμ cells[5].Endomorphin 1 (1-10 μM) increases interleukin-8 secretion in Caco-2 cells[6].Endomorphin 1 (1 μM) inhibits excitatory transmission in adult rat substantia gelatinosa neurons[7]. | ||||||
| Name | Endomorphin 1 | ||||||
| CAS | 189388-22-5 | ||||||
| Sequence | Tyr-Pro-Trp-Phe-NH2 | ||||||
| Shortening | YPWF-NH2 | ||||||
| Formula | C34H38N6O5 | ||||||
| Molar Mass | 610.70 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
Endomorphin 1
CAS: 189388-22-5 F: C34H38N6O5 W: 610.70
Endomorphin 1, a high affinity, highly selective agonist of the μ-opioid receptor (Ki: 1.11 nM), displays reasonable af
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