| Bioactivity | Encephalitic alphavirus-IN-1 has antiviral activity for VEEV and EEEV with EC50s of 0.24 μM and 0.16 μM, respectively. Encephalitic alphavirus-IN-1 has robust mouse plasma stability, and no obvious cytotoxicity[1]. |
| Target | EC50: 0.24 μM (VEEV), 0.16 μM (EEEV) |
| Invitro | Encephalitic alphavirus-IN-1 (1 and 5 μM; 18 hours) reduces substantial VEEV and EEEV in human brain primary neuronal cells[1]. |
| Name | Encephalitic alphavirus-IN-1 |
| Formula | C27H25FN6O2 |
| Molar Mass | 484.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ryan MC, et al. Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones. ACS Med Chem Lett. 2022;13(4):546-553. Published 2022 Mar 14. |
Encephalitic alphavirus-IN-1
CAS: F: C27H25FN6O2 W: 484.52
Encephalitic alphavirus-IN-1 has antiviral activity for VEEV and EEEV with EC50s of 0.24 μM and 0.16 μM, respectively.
Data collection：peptidedb@qq.com
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