| Bioactivity | Enasidenib-d6 (AG-221-d6)is the deuterium labeledEnasidenib(HY-18690)[1]. Enasidenib is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively[2]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 |
| Name | Enasidenib-d6 |
| CAS | 2095569-76-7 |
| Formula | C19H11D6F6N7O |
| Molar Mass | 479.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. |
Enasidenib-d6
CAS: 2095569-76-7 F: C19H11D6F6N7O W: 479.41
Enasidenib-d6 (AG-221-d6)is the deuterium labeledEnasidenib(HY-18690). Enasidenib is an oral, potent, reversible, select
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