| Bioactivity | Enadoline (CI-977) hydrochloride is a highly selective, brain-penetrating, and nonpeptide kappa-opioid receptor (KOR) agonist (Ki=1.25 nM). Antinociceptive effects[1][2]. |
| In Vivo | Enadoline (i.v.; dose of e 15 min before surgery; male Sprague-Dawley rats) hydrochloride dose-dependently (1-100 μg/kg) blocks the development of thermal hyperalgesia as well as static and dynamic allodynia for over 24 h with respective MEDs (minimum effective doses) of < or = 1, 10 and 10 μg/kg[2]. |
| Name | Enadoline hydrochloride |
| CAS | 124439-07-2 |
| Formula | C24H33ClN2O3 |
| Molar Mass | 432.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Field MJ, et al. Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain. Pain. 1999;80(1-2):383-389. [2]. Vanderah TW, Largent-Milnes T, Lai J, et al. Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors. Eur J Pharmacol. 2008;583(1):62-72. |
Enadoline hydrochloride
CAS: 124439-07-2 F: C24H33ClN2O3 W: 432.98
Enadoline (CI-977) hydrochloride is a highly selective, brain-penetrating, and nonpeptide kappa-opioid receptor (KOR) ag
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