| Bioactivity | Emlenoflast (MCC7840), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. Emlenoflast can be used for the research of inflammatory diseases[1][2]. |
| Invitro | Emlenoflast, a MCC950 analogue, shows useful activity in the inhibition of activation of the NLRP3 inflammasome, with an IC50 of <100 nM[1]. |
| In Vivo | Emlenoflast (4 mg/kg; i.v.) exhibits the half-life (3.39 h), AUC0-last (107097 ng•h/mL) and CL (0.621 mL/min/kg) in mice[2].Emlenoflast (20 mg/kg; p.o.) exhibits the oral bioavailability (67.2%), Cmax (60467 ng/mL) and half-life (5.02 h) in mice[2]. Animal Model: |
| Name | Emlenoflast |
| CAS | 1995067-59-8 |
| Formula | C19H24N4O3S |
| Molar Mass | 388.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. El-Sharkawy LY, et, al. Inhibiting the NLRP3 Inflammasome. Molecules. 2020 Nov 25;25(23):5533. [2]. O'neill L, et, al. Sulfonylureas and related compounds and use of same. WO2016131098A1. |