Eltoprazine dihydrochloride_product_DataBase

Bioactivity	Eltoprazine (DU 28853) dihydrochloride is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine dihydrochloride shows antiaggressive and anxiogenic effects[1][2].
In Vivo	大鼠长期接受 Mianserin （10 mg/kg，腹腔注射）或 Eltoprazine（1 mg/kg，腹腔注射）治疗，并在高架十字迷宫测试中进行焦虑测试。Mianserin 和 Eltoprazine 在高架十字迷宫中表现出相反的作用：Mianserin 会产生抗焦虑样作用，而 Eltoprazine 则表现出类焦虑作用[2]。
Name	Eltoprazine dihydrochloride
CAS	143485-51-2
Formula	C12H18Cl2N2O2
Molar Mass	293.19
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sijbesma H, et al. Eltoprazine, a drug which reduces aggressive behaviour, binds selectively to 5-HT1 receptor sites in the rat brain: an autoradiographic study. Eur J Pharmacol. 1990 Feb 20;177(1-2):55-66. [2]. Rocha B, et al. Chronic mianserin or eltoprazine treatment in rats: effects on the elevated plus-maze test and on limbic 5-HT2C receptor levels. Eur J Pharmacol. 1994 Sep 1;262(1-2):125-31.

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