| Bioactivity | Elsamitrucin, derived from actinomycete fermentation, exhibits potent cytotoxicity against a range of murine and human tumor cell lines in vitro, with IC50 values ranging from <0.02 to 3.25 μg/ml after 72-hour exposures. In vivo studies demonstrated significant antitumor activity in various experimental murine tumor models, including P388 leukemia, L1210 leukemia, B16 melanoma, and M5076 sarcoma, when administered intraperitoneally as a water-insoluble free base or as water-soluble lactate or succinate salts. Elsamitrucin also showed efficacy against human MX-1 mammary tumor and HCT116 colon tumor xenografts, highlighting its broad-spectrum cytotoxicity and potential as an antitumor agent across different tumor types and models[1]. |
| CAS | 97068-30-9 |
| Formula | C33H35NO13 |
| Molar Mass | 653.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Elsamitrucin
CAS: 97068-30-9 F: C33H35NO13 W: 653.63
Elsamitrucin, derived from actinomycete fermentation, exhibits potent cytotoxicity against a range of murine and human t
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