| Bioactivity | Elisidepsin (PM02734) is cyclic depsipeptide with antineoplastic activity. Elisidepsin inhibits cancer cell proliferation. Elisidepsin can be used in the research of cancers, such as NSCLC[1][2][3][4]. |
| Invitro | Elisidepsin (72 h) inhibits various cancer cells proliferation with IC50s ranging from 0.4 μM (ZR-75-1) to 8.8 μM (MiaPaCa2)[1].Elisidepsin (1 μM, 48 h) arrests SKBR3 cell in sub-G1 phase[1].Elisidepsin (0-5 μM, 30 min) induces loss of cell membrane integrity in DU145 cells, instead of apoptosis[1].Elisidepsin interacts with glycosylated ceramides in the plasma cell membrane of HCT-116 cells[2].Elisidepsin (0.1 μM, 2 h) is effective in the induction of ErbB3 degradation and dephosphorylation in H322, A549 and H3255 cells[4].Elisidepsin (0.5 and 1 μM, 2 h) inhibits the phosphorylation of ErbB3 and AKT in H322 cells and A549 cells[4]. Cell Viability Assay[1] Cell Line: |
| Name | Elisidepsin |
| CAS | 681272-30-0 |
| Formula | C75H124N14O16 |
| Molar Mass | 1477.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Elisidepsin
CAS: 681272-30-0 F: C75H124N14O16 W: 1477.87
Elisidepsin (PM02734) is cyclic depsipeptide with antineoplastic activity. Elisidepsin inhibits cancer cell proliferatio
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