| Bioactivity | Elemicin-d3 is deuterated labeled Pemafibrate (HY-17618). Pemafibrate is a highly selective PPARα agonist, with an EC50 of 1 nM. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。Elemicin (62.5、125、250、500、1000 μM) 在 HepG2 细胞中的 IC50 值为 910 μM[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Elemicin-d3 相关抗体: |
| In Vivo | Elemicin (500 mg/kg；口服灌胃；每 24 小时一次，持续 3 周) 会损害小鼠的肝功能。Elemicin 抑制肝脏 SCD1，导致溶血磷脂酰胆碱 (LPC) 失衡[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C12H13D3O3 |
| Molar Mass | 211.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Yi-Kun Wang, et al. Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity. J Agric Food Chem. 2019 Jul 24;67(29):8243-8252. [3]. Yang XN, et al. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1. Chem Res Toxicol. 2019 Sep 10. [4]. Xiao-Nan Yang, et al. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1. Chem Res Toxicol. 2019 Oct 21;32(10):1965-1976. [5]. Ayodeji Oluwabunmi Oriola, et al. Essential Oils and Their Compounds as Potential Anti-Influenza Agents. Molecules. 2022 Nov 12;27(22):7797. |