| Bioactivity | Egg oil is a natural oil, which consists primarily of cholesterol, lecithin and glycerides of the fatty acids. Egg oil exhibits activity in regulating the gut microbial dysbiosis, alleviating obesity, insulin resistance and inflammation[1][2][3][4]. | ||||||||||||
| Invitro | Egg oil (0.1-0.8 mg/ml) 可以减少 IL-8 分泌，并通过 Nrf2/NF-kB 信号通路发挥抗炎症活性[2]。Egg oil (10-600 μg/ml) (从海胆中提取) 减弱 7β-OHC 诱导的细胞毒性，调节抗氧化酶的活性并减少 MDA 和 CD 的产生，从而表现出减轻神经退行性疾病的神经保护作用[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Egg oil 相关抗体: Cell Viability Assay[2] Cell Line: | ||||||||||||
| In Vivo | Egg oil (150-600 mg/kg，灌胃，16 周) (从三疣梭子蟹中提取) 可改善胰岛素敏感性和肝糖原合成，通过激活骨骼肌中的 PI3K/Akt/Glu4 信号通路和肝脏中的 PI3K/Akt/GSK3β/GS 信号通路传导来减轻胰岛素抵抗[1]。Egg oil (150-600 mg/kg，灌胃，16 周) (从三疣梭子蟹中提取) 可改善 HFD 诱导的小鼠肥胖，恢复肠道微生物菌群失调并下调肝脏和附睾脂肪中的 LPS/TLR4 通路[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: | ||||||||||||
| CAS | 8001-17-0 | ||||||||||||
| Appearance | 液体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Hu S, et al., Egg oil from Portunus trituberculatus alleviates insulin resistance through activation of insulin signaling in mice. Appl Physiol Nutr Metab. 2019 Oct;44(10):1081-1088. [2]. Xiao N, et al., Egg yolk oils exert anti-inflammatory effect via regulating Nrf2/NF-κB pathway. J Ethnopharmacol. 2021 Jun 28;274:114070. [3]. Hu S, et al., Egg oil from Portunus trituberculatus alleviated obesity and regulated gut microbiota in mice. Sci Rep. 2020 May 21;10(1):8454. [4]. Zarrouk A, et al., 7β-hydroxycholesterol-induced cell death, oxidative stress, and fatty acid metabolism dysfunctions attenuated with sea urchin egg oil. Biochimie. 2018 Oct;153:210-219. |