| Bioactivity | Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol (HY-101071A)[1]. |
| Invitro | Eg5-IN-3 (5) 抑制癌细胞 Eg5 ATPase IC50 值为2.37 ± 0.15 µM。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Eg5-IN-3 相关抗体: |
| Formula | C23H23N7O2 |
| Molar Mass | 429.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Samia A Elseginy, et al. Identifying and characterising promising small molecule inhibitors of kinesin spindle protein using ligand-based virtual screening, molecular docking, molecular dynamics and MM‑GBSA calculations. J Comput Aided Mol Des. 2024 Apr 1;38(1):16. |