| Bioactivity | Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM[1][2]. |
| Invitro | Echinomycin (0-10 nM; 16 hours; U251 cells) treatment significantly inhibits hypoxia-induced VEGF mRNA expression in a dose-dependent fashion. Echinomycin very potently inhibits hypoxic induction of luciferase expression in U251-HRE in a dose-dependent fashion with an EC50 of 1.2 nM[1]. RT-PCR[1] Cell Line: |
| Name | Echinomycin |
| CAS | 512-64-1 |
| Formula | C51H64N12O12S2 |
| Molar Mass | 1101.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
Echinomycin
CAS: 512-64-1 F: C51H64N12O12S2 W: 1101.26
Echinomycin (Quinomycin A) ispotent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DN
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.