| Bioactivity | EcDsbB-IN-9 (Compound 9) is a potent E. coli DsbB (EcDsbB) inhibitor with an IC50 of 1.7 μM and a Ki of 46 nM[1]. | ||||||||||||
| Target | IC50: 1.7 μM (EcDsbB)Ki: 46 nM (EcDsbB) | ||||||||||||
| Invitro | EcDsbB-IN-9 (Compound 9) (0-100 μM) causes accumulation of reduced DsbA (EcDsbB substrate) and inhibits oxidation of DsbA with an IC50 of 8.5 ± 0.6 μM[1]. | ||||||||||||
| Name | EcDsbB-IN-9 | ||||||||||||
| CAS | 41933-33-9 | ||||||||||||
| Formula | C11H8Cl2N2O | ||||||||||||
| Molar Mass | 255.10 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Landeta C, et al. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. Nat Chem Biol. 2015 Apr;11(4):292-8. |