| Bioactivity | PF-06873600 is a selective and orally bioavailable inhibitor of cyclin-dependent kinase (CDK), with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively. PF-06873600 has potential antineoplastic activity[1][2]. | ||||||||||||
| Invitro | PF-06873600 (Example 8) 是一种具有口服生物利用度的细胞周期蛋白依赖性激酶 (CDK) 抑制剂，具有潜在的抗肿瘤活性[1]。PF-06873600 选择性靶向、结合并抑制 CDK 的活性。这些激酶的抑制导致细胞周期停滞、细胞凋亡的诱导和肿瘤细胞增殖的抑制。CDK 是 ATP 依赖性丝氨酸/苏氨酸激酶，是细胞周期进程和细胞增殖的重要调节因子，在肿瘤细胞中经常过度表达[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Ebvaciclib 相关抗体: | ||||||||||||
| CAS | 2185857-97-8 | ||||||||||||
| Formula | C20H27F2N5O4S | ||||||||||||
| Molar Mass | 471.52 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. US 2018/0044344 A1. [2]. NCI Drug Dictionary |
Ebvaciclib
CAS: 2185857-97-8 F: C20H27F2N5O4S W: 471.52
PF-06873600 is a selective and orally bioavailable inhibitor of cyclin-dependent kinase (CDK), with Ki values of 0.09 nM
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