| Bioactivity | Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss [1]. |
| Invitro | Ebselen derivative 1 (Compound 19) (100 μM) 在毛细胞中显著减少了顺铂 (HY-17394) 诱导的凋亡和铁死亡并且缓解了顺铂在整个耳蜗中触发的氧化应激激增[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Ebselen derivative 1 相关抗体: |
| In Vivo | Ebselen derivative 1 (Compound 19) (80 mg/kg; 口服; 一天一次连续 一周) 在 C57BL/6 小鼠中具有听力保护作用，可以缓解顺铂 (5 mg/kg; 腹腔注射; 在 Ebselen derivative 1 给药的第三天和第七天分别一次) (HY-17394) 诱导毛细胞损失[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 3030492-59-9 |
| Formula | C13H10N2O2Se |
| Molar Mass | 305.19 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang W, et al. Quantum chemistry calculation-aided discovery of potent small-molecule mimics of glutathione peroxidases for the treatment of cisplatin-induced hearing loss. Eur J Med Chem. 2024;271:116404. |
Ebselen derivative 1
CAS: 3030492-59-9 F: C13H10N2O2Se W: 305.19
Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demo
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.