| Bioactivity | Ebiratide (HOE-427) TFA is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide TFA enhances acetycholine (ACh) metabolism in rat brain[1][2]. | ||||||
| In Vivo | Ebiratide (0.1-30 μg/kg，皮下注射，单剂量) TFA 对电惊厥休克和 Scopolamine (HY-N0296) 诱导的小鼠模型中的记忆障碍具有神经保护功效，并具有抗遗忘功效[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: | ||||||
| Sequence | {Met(O2)}-Glu-His-Phe-{d-Lys}-{Phe-NH(CH2)8NH2} | ||||||
| Shortening | {Met(O2)}-EHF-{d-Lys}-{Phe-NH(CH2)8NH2} | ||||||
| Formula | C48H73N11O10S.xC2HF3O2 | ||||||
| Molar Mass | 996.23 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Hock FJ, et al., Learning and memory processes of an ACTH4-9 analog (ebiratide; Hoe 427) in mice and rats. Peptides. 1988 May-Jun;9(3):575-81. [2]. G Wiemer, et al. Neurochemical effects of the synthetic ACTH4-9-analog Hoe 427 (Ebiratide) in rat brain. Peptides. 1988 Sep-Oct;9(5):1081-7. |
Ebiratide TFA
CAS: F: C48H73N11O10S.xC2HF3O2 W: 996.23 (free base)
Ebiratide (HOE-427) TFA is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory
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