| Bioactivity | ERα17p (ERα 295-311) is the epitope of the CaM binding site on the estrogen receptor α (ER) (ER), which interacts with calmodulin (CaM) in a calcium-dependent manner. ERα17p regulates the migration of cancer cells MCF-7, SK-BR-3, T47D and MDA-MB-231 through Rho/ROCK and PI3K/Akt signaling pathway. ERα17p inhibits proliferation of breast cancer cells, induces apoptosis and inhibits tumor growth in mouse model[1][2][3]. |
| CAS | 938077-77-1 |
| Sequence | Pro-Leu-Met-Ile-Lys-Arg-Ser-Lys-Lys-Asn-Ser-Leu-Ala-Leu-Ser-Leu-Thr |
| Shortening | PLMIKRSKKNSLALSLT |
| Formula | C84H154N24O23S |
| Molar Mass | 1900.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kampa M, et al., ERα17p, an ERα P295 -T311 fragment, modifies the migration of breast cancer cells, through actin cytoskeleton rearrangements. J Cell Biochem. 2011 Dec;112(12):3786-96. [2]. Bourgoin-Voillard S, et al. Calmodulin association with the synthetic ERα17p peptide investigated by mass spectrometry[J]. International Journal of Mass Spectrometry, 2011, 305(2-3): 87-94. [3]. Pelekanou V, et al., The estrogen receptor alpha-derived peptide ERα17p (P(295)-T(311)) exerts pro-apoptotic actions in breast cancer cells in vitro and in vivo, independently from their ERα status. Mol Oncol. 2011 Feb;5(1):36-47. |