| Bioactivity | ERα degrader 7 (compound B1) is a potent ERα degrader with an IC50 of 14.6 nM and a DC50 of 9.7 nM, respectively. ERα degrader 7 shows excellent antitumor activity, indicating its potential to evolve as a promising selective estrogen-receptor degrader (SERD) for breast cancer research[1]. |
| Target | IC50: 14.6 nM (ERα) |
| Invitro | ERα degrader 7 (10-5-10 μM, 5 d) 对乳腺癌细胞表现出抗肿瘤活性 (IC50 = 4.21 nM) 且对正常乳腺上皮细胞无细胞毒性[1]。ERα degrader 7 (50-1000 nM, 5 d)对 MCF-7 中 ERα 表现出显著的浓度依赖性降解效果[1]。 0 --> ERα degrader 7 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| Name | ERα degrader 7 |
| Formula | C28H24F4N2O3 |
| Molar Mass | 512.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Haohao Zhu, et al. Hot-Spot Residue-Based Virtual Screening of Novel Selective Estrogen-Receptor Degraders for Breast Cancer Treatment. Journal of Chemical Information and Modeling. 2023, Article ASAP. |