| Bioactivity | ERRγ agonist-2 is a potent and selective ERRγ inverse agonist with a Kd value of 6.5 μM. ERRγ agonist-2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ agonist-2 has antimicrobial, anti-coagulant and antidiabetic activities[1]. |
| Invitro | ERRγ agonist-2 (1-10 μM; 293T 细胞) 抑制 ERRγ 的 PGC-1α 依赖性转录活性，对 ERRα 和 ERRβ 的抑制作用微弱[1]。ERRγ agonist-2 (10 μM; AML12 细胞) 抑制铁调素、纤维蛋白原和糖异生基因的表达[1]。 |
| Name | ERRγ agonist-2 |
| CAS | 324022-01-7 |
| Formula | C27H21N5O2 |
| Molar Mass | 447.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang SH, et, al. Structure-based discovery of pyrazolamides as novel ERRγ inverse agonists. Eur J Med Chem. 2023 Mar 15;250:115174. |
ERRγ agonist-2
CAS: 324022-01-7 F: C27H21N5O2 W: 447.49
ERRγ agonist-2 is a potent and selective ERRγ inverse agonist with a Kd value of 6.5 μM. ERRγ agonist-2 inhibits the
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