ERK-IN-4_product_DataBase

Bioactivity	ERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM. ERK-IN-4 specificity inhibits ERK Rsk-1 and Elk-1 phosphorylation. ERK-IN-4 has little effect on ERK protein phosphorylation by its upstream activator MEK1/2[1].
Invitro	ERK-IN-4（化合物 76；10-75 µM；10 天）完全抑制细胞增殖，并减少细胞集落数量[1]。ERK-IN-4（化合物 76；100 µM）抑制 ERK 介导的 Thr573 上 Rsk-1 磷酸化和 ERK 介导的 HeLa 细胞中的 Elk-1 磷酸化[1]。 Cell Proliferation Assay[1] Cell Line:
Name	ERK-IN-4
CAS	1049738-54-6
Formula	C14H17ClN2O3S
Molar Mass	328.81
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chad N Hancock, et al. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J Med Chem. 2005 Jul 14;48(14):4586-95.

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