| Bioactivity | ER176 is a next generation PET radioligand for imaging 18 kDa translocator protein (TSPO), a biomarker for neuroinflammation[1][2]. |
| Invitro | ER176 shows homozygous high-affinity binders (HABs)/heterozygous mixed affinity binders (MABs) ratio for BP ND (specific-to-non-displaceable ratio of distribution volumes) of 1.2[1]. |
| Name | ER176 |
| CAS | 1373887-29-6 |
| Formula | C20H20ClN3O |
| Molar Mass | 353.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Masahiro Fujita, et al. Comparison of four 11 C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios. EJNMM [2]. Jason C Mixdorf, et al. Alternative strategies for the synthesis of [ 11 C]ER176 for PET imaging of neuroinflammation. Appl Radiat Isot. 2021 Sep 17;178:109954. |