| Bioactivity | ER-DRI is a potent peptide inhibitor that tagets EV-A71. ER-DRI directly bounds to 3A and specifically abrogates viral suppressor of RNAi activity, which unlocked the antiviral RNAi response that is suppressed by 3A. ER-DRI also potently inhibits another enterovirus, Coxsackievirus-A16, dependently of RNAi[1]. |
| Sequence | d-(Arg-Cys-Tyr-Gln-Arg-Val-Glu-Glu-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly-Tyr) |
| Shortening | d-(RCYQRVEEPPRRRQRRKKRGY) |
| Formula | C118H201N49O30S |
| Molar Mass | 2818.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fang Y, et al. Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo. Immunity. 2021 Oct 12;54(10):2231-2244.e6. |