EPZ033294_product_DataBase

Bioactivity	EPZ033294 is an inhibitor of SYMD2 (IC50 is 3.9 nM). SYMD2 itself has catalytic activity and can methylate the lysine residue of BTF3 to BTF3me1, which was experimentally demonstrated by detecting an IC50 of 2.9 nM for inhibition of BTF3ME1 by SYMD2, indicating an active inhibition of SYMD2 by EPZ033294. EPZ033294 (0-50 µM) has an inhibitory effect on SYMD2 and a concentration-dependent inhibitory effect in 293T[1].
Target	SYMD2
Invitro	EPZ033294 (0-50 µM) 在 293T 细胞中抑制 SMYD2 且有浓度依赖性的抑制作用[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> EPZ033294 相关抗体: Western Blot Analysis[1] Cell Line:
CAS	1887195-17-6
Formula	C20H22ClN7O
Molar Mass	411.89
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Edoardo Fabini, et al. Small-molecule inhibitors of lysine methyltransferases SMYD2 and SMYD3: current trends. Medicinal Chemistry. 2019 Apr;11(8):901-921. [2]. Michael J, et al. Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. PLOS ONE. 2018 Jun 1;13(6):e0197372.

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