| Bioactivity | EPZ-4777 is a selective DOT1L inhibitor which inhibits H3K79 methylation in cancer cells, blocks the expression of leukemogenic genes, and selectively kills cells that contain the translocation. EPZ-4777 can be used for cancer research[1]. |
| Invitro | EPZ-4777 (1-10000 nM, 24, 72 h) 剂量与时间依赖性地抑制 MOLM-13 细胞 HOXA9 和 LSD1 的表达[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> EPZ-4777 相关抗体: |
| CAS | 1381761-52-9 |
| Formula | C27H40N8O4 |
| Molar Mass | 540.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bon C, et al. Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein. Molecules. 2021 Aug 31;26(17):5300. [2]. Lillico R, et al. Selective DOT1L, LSD1, and HDAC Class I Inhibitors Reduce HOXA9 Expression in MLL-AF9 Rearranged Leukemia Cells, But Dysregulate the Expression of Many Histone-Modifying Enzymes. J Proteome Res. 2018 Aug 3;17(8):2657-2667. |
EPZ-4777
CAS: 1381761-52-9 F: C27H40N8O4 W: 540.66
EPZ-4777 is a selective DOT1L inhibitor which inhibits H3K79 methylation in cancer cells, blocks the expression of leuke
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.