| Bioactivity | EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells. |
| Target | IC50: 4 µM (Epac) |
| Invitro | Epac is a key mediator of cAMP signaling. EPAC 5376753, the thiobarbituric acid modification of 5225554, has a greater ability to decrease the conformational changes of Epac necessary for its activation and to inhibit Epac signaling in cells. 5376753 selectively inhibits Epac-mediated migration in fibroblasts[1]. |
| Name | EPAC 5376753 |
| CAS | 302826-61-5 |
| Formula | C15H8Cl2N2O3S |
| Molar Mass | 367.21 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Brown LM, et al. Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors. J Biol Chem. 2014 Oct 17;289(42):29148-57. |
EPAC 5376753
CAS: 302826-61-5 F: C15H8Cl2N2O3S W: 367.21
EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.