| Bioactivity | EP652 (compound 56) potently inhibits the enzymatic activity of METTL3, with the IC50s of 2 nM, ＜ 10 nM anf 37 nM in SPA, intracellular and ATPlite assay, respectively. EP652 plays an important role in liquid and solid tumors research[1]. |
| CAS | 3050819-22-9 |
| Formula | C25H34N8O |
| Molar Mass | 462.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Guillaume Dutheuil, et al. Discovery, Optimization, and Preclinical Pharmacology of EP652, a METTL3 Inhibitor with Efficacy in Liquid and Solid Tumor Models. J Med Chem. 2025 Jan 30. |