| Bioactivity | EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes[1]. |
| Name | EP3 antagonist 4 |
| CAS | 2408297-80-1 |
| Formula | C22H20Cl3FN4O3S2 |
| Molar Mass | 577.91 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhu B, et al. Discovery and Optimization of 7-Alkylidenyltetrahydroindazole-Based Acylsulfonamide EP3 Antagonists. ACS Med Chem Lett. 2021 Dec 7;13(1):111-117. |
EP3 antagonist 4
CAS: 2408297-80-1 F: C22H20Cl3FN4O3S2 W: 577.91
EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo
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