EP2 receptor antagonist-2_product_DataBase

Bioactivity	EP2 receptor antagonist-2 (CID891729) is an antagonist of EP2 receptor. EP2 receptor antagonist-2 inhibits the EP2 receptor activation induced by PGE2. EP2 receptor antagonist-2 also suppresses lactate dehydrogenase (LDH) release induced by N-methyl-D-aspartate (NMDA)[1].
Invitro	EP2 receptor antagonist-2 对 C6G 细胞具有细胞毒性，CC50 为 575 μM[1]。EP2 receptor antagonist-2 (20 μM；30 min) 降低大鼠原代海马神经元 (DIV14) 中 NMDA (30 μM) 诱导的 LDH 释放[1]。
Name	EP2 receptor antagonist-2
CAS	615273-95-5
Formula	C15H14F3N3O
Molar Mass	309.29
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Jiang J, et al. Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2. ACS Chem Neurosci. 2018 Apr 18;9(4):699-707.

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