| Bioactivity | ENT-C225 is an effective activator of TrkB neurotrophin receptor. ENT-C225 has high effect on activating TrkB receptor (TrkBR), and has good physicochemical properties and neuroprotective properties[1]. |
| Invitro | ENT-C225 (Compound 10) (1 µM；24 h) 显著改善 NIH-3T3 TrkB 细胞毒性，降低细胞死亡率[1]。ENT-C225 (1 µM；20 min) 促进 NIH-3T3 TrkB 细胞和原代星形胶质细胞中的 TrkB 受体磷酸化[1]。ENT-C225 (500 pM-1 µM；48 h) 具有显著的神经保护作用且以剂量依赖性的方式增强。ENT-C225 促进脊髓运动神经元的神经网络和细胞质中 TAR DNA 结合蛋白 43 (TDP43) 的积累[1]。 |
| Name | ENT-C225 |
| Formula | C26H40N4O5 |
| Molar Mass | 488.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Antonijevic M, et al. Design, synthesis and biological characterization of novel activators of the TrkB neurotrophin receptor. Eur J Med Chem. 2023 Feb 15;248:115111. |