| Bioactivity | EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism[1]. | ||||||||||||
| Name | EN450 | ||||||||||||
| CAS | 793719-01-4 | ||||||||||||
| Formula | C11H13ClN2O3S | ||||||||||||
| Molar Mass | 288.75 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. King EA, et al. Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB. Cell Chem Biol. 2023 Apr 20;30(4):394-402.e9. |
EN450
CAS: 793719-01-4 F: C11H13ClN2O3S W: 288.75
EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.