| Bioactivity | EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol[1]. |
| CAS | 2191110-79-7 |
| Formula | C17H22N2O |
| Molar Mass | 270.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shao Q, et al. Targeted Protein Localization by Covalent 14-3-3 Recruitment. J Am Chem Soc. 2024 Sep 11;146(36):24788-24799. |