| Bioactivity | EM12-SO2F is a powerful covalent inhibitor of CRBN through binding at His353. EM12-SO2F is a useful chemical probe to investigate the CRBN. EM12-SO2F inhibits the degradation of IKZF1 by lenalidomide (HY-A0003) in MOLT4 cells[1][2] |
| Name | EM12-SO2F |
| CAS | 2803819-61-4 |
| Formula | C13H11FN2O5S |
| Molar Mass | 326.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lang Zheng, et al. Development of covalent inhibitors: Principle, design, and application in cancer. Volume2, Issue 4.December 2023. [2]. Cruite JT, et al. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem Biol. 2022 Jul 8;3(9):1105-1110. |
EM12-SO2F
CAS: 2803819-61-4 F: C13H11FN2O5S W: 326.30
EM12-SO2F is a powerful covalent inhibitor of CRBN through binding at His353. EM12-SO2F is a useful chemical probe to in
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