| Bioactivity | ELQ-598, as a prodrug, is converted into the active drug ELQ-596 upon oral administration. ELQ-598 demonstrates potent parasitic growth inhibition capabilities (IC50= 37 nM). ELQ-598 also shows low toxicity towards human cells (IC50= 19 μM). ELQ-598 can be used for research into babesiosis[1]. |
| In Vivo | ELQ-598 (10 mg/kg; p.o.; 感染后第三天到第七天) 完全消除了 C3H 小鼠的邓肯芽孢杆菌感染[1]。ELQ-598 (10 mg/kg; p.o.; 感染后第三天到第七天) 可有效消除小鼠的微小芽孢杆菌感染[1]。ELQ-598 (10 mg/kg; p.o.; 感染后第三天到第七天) 联合 atovaquone (HY-13832) 可以消除 C3H/HeJ 小鼠中的邓肯芽孢杆菌感染和 SCID 小鼠的微小芽孢杆菌感染[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 3023709-99-8 |
| Formula | C28H23ClF3NO6 |
| Molar Mass | 561.93 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Vydyam P, et al. Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis. ACS Infect Dis. 2024 Apr 12;10(4):1405-1413. |
ELQ-598
CAS: 3023709-99-8 F: C28H23ClF3NO6 W: 561.93
ELQ-598, as a prodrug, is converted into the active drug ELQ-596 upon oral administration. ELQ-598 demonstrates potent p
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