| Bioactivity | ELP-004 is a TRPC channel inhibitor and inhibtis TRPC channel-mediated Ca2+ entry. ELP-004 is an osteoclast inhibitor and inhibits osteoclast differentiation. ELP-004 inhibits basal Ca2+ and related NFATc1 translocation in inflammatory osteoclastogenesis. ELP-004 reduces bone erosion in a mouse model of rheumatoid arthritis[1][2]. |
| CAS | 15533-81-0 |
| Formula | C10H11Cl2NO |
| Molar Mass | 232.11 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ray S, et al. Targeting TRPC channels for control of arthritis-induced bone erosion. Sci Adv. 2025 Jan 17;11(3):eabm9843. [2]. McCall JL, et al. Preclinical evaluation of ELP-004 in mice. Pharmacol Res Perspect. 2024 Aug;12(4):e1230. |