| Bioactivity | EGFR/microtubule-IN-1 (Compound 10c) is a dual inhibitor targeting EGFR and tubulin. The IC50 for inhibiting EGFR is 10.66 nM. EGFR/microtubule-IN-1 can reduce the phosphorylation levels of EGFR, AKT and ERK, hinder tubulin polymerization, and induce apoptosis[1]. |
| Target | 10.66 nM (EGFR) |
| Name | EGFR/microtubule-IN-1 |
| CAS | 1970269-96-5 |
| Formula | C23H18BrN5O3 |
| Molar Mass | 492.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu Y, et al. Design of balanced dual-target inhibitors of EGFR and microtubule. Bioorg Chem. 2024 Feb;143:107087. |
EGFR/microtubule-IN-1
CAS: 1970269-96-5 F: C23H18BrN5O3 W: 492.32
EGFR/microtubule-IN-1 (Compound 10c) is a dual inhibitor targeting EGFR and tubulin. The IC50 for inhibiting EGFR is 10.
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