| Bioactivity | EGFR/HER2-IN-15, a dihydropyrimidine, is a potent EGFR/HER2 inhibitor. EGFR/HER2-IN-15 significantly inhibits EGFRwt activity with an IC50 of 37.21 nM. EGFR/HER2-IN-15 has anticaner effects[1]. |
| Invitro | 浓度为 1000 nM 时，EGFR/HER2-IN-15（化合物 21）对 EGFR 和 HER2 表达的抑制率分别为 98.51% 和 96.79%[1]。EGFR/HER2-IN-15 抑制 MCF-7 乳腺癌细胞，IC50 为 9.38 μM。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> EGFR/HER2-IN-15 相关抗体: |
| Formula | C28H29N3O6 |
| Molar Mass | 503.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Syed Faizanm, et al. Novel dihydropyrimidines as promising EGFR & HER2 inhibitors: Insights from experimental and computational studies. Eur J Med Chem. 2024 Jun 19:275:116607. |