EGFR/HER2-IN-11_product_DataBase

Bioactivity	EGFR/HER2-IN-11 (compound 20) is an orally active dual inhibitor for human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), with IC50s of 7.7 and 22 nM, respectively. EGFR/HER2-IN-11 exhibits antitumor efficacy and inhibits proliferation against cancer cells BT-474 with GI50 of 601 nM[1].
In Vivo	EGFR/HER2-IN-11 (10 mg/kg，口服) 在 BALB/c 小鼠体内的代谢稳定性为 59 μL/min/mg，AUC0-8 h 为 2.476 μg·h/mL[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1346176-20-2
Formula	C23H21ClF3N5O2
Molar Mass	491.89
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ishikawa T, et al., Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold. J Med Chem. 2011 Dec 8;54(23):8030-50.

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