| Bioactivity | EGFR/DHFR-IN-1 (Compound 10e) is a dual inhibitor of EGFR and DHFR with IC50s of 0.151 and 0.541 µM, respectively. EGFR/DHFR-IN-1 arrests the cell cycle at both G0-G1 and S phases[1]. |
| Formula | C24H26N4O5S2 |
| Molar Mass | 514.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fouad M M, et al. Synthesis and in vitro antitumor evaluation of new thieno [2, 3-d] pyrimidine derivatives as EGFR and DHFR inhibitors[J]. Bioorganic Chemistry, 2024, 148: 107401. |