EGFR ligand-2_product_DataBase

CAS: 2737283-20-2 F: C30H35N9O W: 537.66

EGFR ligand-2 (compound C4), a covalent EGFR ligand, is a EGFR mutant inhibitor with IC50s of 21 nM and 48 nM for EGFRL8

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	EGFR ligand-2 (compound C4), a covalent EGFR ligand, is a EGFR mutant inhibitor with IC50s of 21 nM and 48 nM for EGFRL858R and EGFRL858R/T790M, respectively. EGFR ligand-2 can be used to synthesize PROTAC[1].
Name	EGFR ligand-2
CAS	2737283-20-2
Formula	C30H35N9O
Molar Mass	537.66
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hong-Yi Zhao, et al. Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands. J Med Chem. 2022 Mar 24;65(6):4709-4726.

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