| Bioactivity | EGFR T790M/L858R-IN-3 (compound B1) is a EGFRL858R/T790M inhibitor with IC50 value of 13?nM. EGFR T790M/L858R-IN-3 shows anti-tumour activity in H1975 cells with an IC50 value of 0.087 μΜ. EGFR T790M/L858R-IN-3 inhibits cell migration in A549 cells and induces apoptosis in H1975 cells[1]. |
| Name | EGFR T790M/L858R-IN-3 |
| Formula | C28H32ClN7O2S2 |
| Molar Mass | 598.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fu J, et al. Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives as novel EGFRL858R/T790M inhibitors. J Enzyme Inhib Med Chem. 2023;38(1):2205605. |
EGFR T790M/L858R-IN-3
CAS: F: C28H32ClN7O2S2 W: 598.18
EGFR T790M/L858R-IN-3 (compound B1) is a EGFRL858R/T790M inhibitor with IC50 value of 13?nM. EGFR T790M/L858R-IN-3 shows
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