EGFR-IN-97_product_DataBase

Bioactivity	EGFR-IN-97 (compound 6q) is a EGFR inhibitor. EGFR-IN-97 shows inhibitory activity against Ba/F3-EGFRL858R/T790M/C797S and Ba/F3-EGFRDel19/T790M/C797S cells, with IC50 values of 0.42 μM and 0.41 μM, respectively. EGFR-IN-97 can promote apoptosis of NCI-H1975-EGFRL858R/T790M/C797S cells at the concentration of 0.8 μM[1].
Invitro	EGFR-IN-97 (compound 6q) 对突变型NSCLC细胞系NCI-H1975-EGFRL858R/T790M/C797S细胞表现出优异的活性，IC50值为0.82 μM，优于 osimertinib (HY-15772) (IC50 = 2.94 μM)、JBJ-04-125-02 (HY-135805) (IC50 = 3.66 μM)，以及 JBJ-04-125-02 和 osimertinib 共同给药(IC50 = 1.25 μM)[1]。 0 --> EGFR-IN-97 相关抗体:
Name	EGFR-IN-97
CAS	3020681-05-1
Formula	C37H36N8O2
Molar Mass	624.73
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hu L, et al. Identification of novel aminopyrimidine derivatives for the treatment of mutant NSCLC. Eur J Med Chem. 2023 Dec 20;265:116074.

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