| Bioactivity | EGFR-IN-90 (compound 34) is an orally active EGFR inhibitor. EGFR-IN-90 shows inhibitory activity against EGFRL858R/T790M/C797S with an IC50 of 5.1 nM and inhibits the proliferation of the H1975-TM cell line harboring EGFRL858R/T790M/C797S with an IC50 of 0.05 μM. EGFR-IN-90 and inhibits tumor growth in the H1975-TM xenograft tumor model[1]. |
| Target | 5.1 nM(EGFR) |
| Name | EGFR-IN-90 |
| Formula | C32H36FN7O2S2 |
| Molar Mass | 633.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhu Y, et al. Discovery of Novel Fourth-Generation EGFR Inhibitors to Overcome C797S-Mediated Resistance. J Med Chem. 2023;66(21):14633-14652. |